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EC 2.3.1.257 Details
EC number
2.3.1.257
Accepted name
N-terminal L-serine Nα-acetyltransferase NatD
Reaction
(1) acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal-Nα-acetyl-L-seryl-[histone H4] + CoA;;(2) acetyl-CoA + an N-terminal-L-seryl-[histone H2A] = an N-terminal-Nα-acetyl-L-seryl-[histone H2A] + CoA
Other name(s)
NAA40 (gene name)
Systematic name
acetyl-CoA:N-terminal-L-seryl-[histone 4/2A] L-serine Nα-acetyltransferase
Comment
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free α-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. NatD is found in all eukaryotic organisms, and acetylates solely the serine residue at the N-terminus of histones H2A or H4. Efficient recognition and acetylation by NatD requires at least the first 30 to 50 highly conserved amino acid residues of the histone N terminus.
History
created 1989 as EC 2.3.1.88, part transferred 2016 to EC 2.3.1.257
EC Tree
1.1.3.1 created 1961, deleted 1984
1.1.3.22 created 1961 as EC 1.2.3.2, transferred 1984 to EC 1.1.3.22, modified 1989, deleted 2004
1.1.3.25 created 1986, deleted 2005
1.1.3.26 created 1989, deleted 2002
1.1.3.31 created 1992, deleted 2003
1.1.3.32 created 1999, deleted 2002
1.1.3.33 created 1999, deleted 2002
1.1.3.34 created 1999, deleted 2002
1.1.3.35 created 1999, deleted 2002
1.1.3.36 created 1999, deleted 2002
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003