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EC 2.7.1.199 Details
EC number
2.7.1.199
Accepted name
protein-Nπ-phosphohistidine—D-glucose phosphotransferase
Reaction
[protein]-Nπ-phospho-L-histidine + D-glucose[side 1] = [protein]-L-histidine + D-glucose 6-phosphate[side 2]
Other name(s)
ptsG (gene name), D-glucose PTS permease, EIIGlc, Enzyme IIGlc
Systematic name
protein-Nπ-phospho-L-histidine:D-glucose Nπ-phosphotransferase
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate—protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.199
EC Tree
1.1.1.68 created 1965, deleted 1978 [transferred to EC 1.1.99.15, deleted 1980]
1.1.1.70 created 1965, deleted 1978
1.1.1.74 created 1972, deleted 1976
1.1.1.89 created 1972, deleted 1976
1.1.1.109 created 1972, deleted 1976
1.1.1.139 created 1972, deleted 1978
1.1.1.155 created 1976, deleted 2004
1.1.1.171 created 1978, deleted 1984
1.1.1.180 created 1983, deleted 1984
1.1.1.182 created 1983, deleted 1990
1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004
1.1.1.242 created 1992, deleted 2001
1.1.1.249 provisional version created 1999, deleted 1999 (reinstated 2001 as EC 2.5.1.46)
1.1.1.253 created 1999, deleted 2003
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003