EC Explorer

2.1.1.362

[histone H4]-N-methyl-L-lysine²⁰ N-methyltransferase

S-adenosyl-L-methionine + a [histone H4]-N⁶-methyl-L-lysine²⁰ = S-adenosyl-L-homocysteine + a [histone H4]-N⁶,N⁶-dimethyl-L-lysine²⁰

KMT5B (gene name), KMT5C (gene name), SUV420H1 (gene name), SUV420H2 (gene name)

S-adenosyl-L-methionine:[histone H4]-N⁶-methyl-L-lysine²⁰ N⁶-methyltransferase

This entry describes a group of enzymes that catalyse a single methylation of monomethylated lysine²⁰ of histone H4 (H4K20m1, generated by EC 2.1.1.361, [histone H4]-lysine²⁰ N-methyltransferase), forming the dimethylated form. This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes. The double-methylated form of lysine²⁰ in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules. Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated.

created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.362