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EC 1.14.99.40 Details
EC number
1.14.99.40
Accepted name
5,6-dimethylbenzimidazole synthase
Reaction
FMNH2 + NADH + H+ + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + other product
Other name(s)
BluB
Systematic name
FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming)
Comment
The C-2 of 5,6-dimethylbenzimidazole is derived from C-1′ of the ribityl group of FMNH2 and 2-H from the ribityl 1′-pro-S hydrogen. The other product may be barbituric acid. For a possible mechanism click here. The stoichiometery of the reaction is not known.
History
created 2010, deleted 2014
EC Tree
1.1.5.1 created 1983, deleted 2002
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003