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EC 3.6.4.12 Details
show Brenda entryEC number
3.6.4.12
Accepted name
DNA helicase
Reaction
ATP + H2O = ADP + phosphate
Other name(s)
3&prime,
to 5&prime,
DNA helicase,
3′-5&prime,
DNA helicase,
3′-5&prime,
PfDH,
5&prime,
to 3&prime,
DNA helicase,
AvDH1,
BACH1 helicase,
BcMCM,
BLM protein,
BRCA1-associated C-terminal helicase,
CeWRN-1,
Dbp9p,
DmRECQ5,
DNA helicase 120,
DNA helicase A,
DNA helicase E,
DNA helicase II,
DNA helicase III,
DNA helicase RECQL5β,
DNA helicase VI,
dnaB (gene name),
DnaB helicase E1,
helicase HDH IV,
Hel E,
helicase DnaB,
helicase domain of bacteriophage T7 gene 4 protein helicase,
PcrA helicase,
UvrD,
hHcsA,
Hmi1p,
hPif1,
MCM helicase,
MCM protein,
MER3 helicase,
MER3 protein,
MPH1,
PcrA,
PDH120,
PfDH A,
Pfh1p,
PIF1
Systematic name
ATP phosphohydrolase (DNA helix unwinding)
Comment
DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. Some of them unwind duplex DNA with a 3′ to 5′ polarity [1,3,5,8], others show 5′ to 3′ polarity [10,11,12,13] or unwind DNA in both directions [14,15]. Some helicases unwind DNA as well as RNA [9,10]. May be identical with EC 3.6.4.13 (RNA helicase).
History
created 2009, deleted 2021
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.5.1 created 1983, deleted 2002 1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
