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EC 1.17.7.3 Details
show Brenda entryEC number
1.17.7.3
Accepted name
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)
Reaction
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin
Other name(s)
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ambiguous),
(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect),
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (ambiguous),
ispG (gene name)
Systematic name
(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized flavodoxin oxidoreductase
Comment
A bacterial iron-sulfur protein that contains a [4Fe-4S] cluster. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria [2]. Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).
History
created 2014
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.5.1 created 1983, deleted 2002 1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
