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EC 4.2.3.124 Details
show Brenda entryEC number
4.2.3.124
Accepted name
2-deoxy-scyllo-inosose synthase
Reaction
D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate
Other name(s)
btrC (gene name),
neoC (gene name),
kanC (gene name)
Systematic name
D-glucose-6-phosphate phosphate-lyase (2-deoxy-L-scyllo-inosose-forming)
Comment
Requires Co2+ [2]. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Requires an NAD+ cofactor, which is transiently reduced during the reaction [1,4]. The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5′-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex [6,7].
History
created 2012
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002 1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
