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EC 4.2.3.124 Details
EC number
4.2.3.124
Accepted name
2-deoxy-scyllo-inosose synthase
Reaction
D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate
Other name(s)
btrC (gene name), neoC (gene name), kanC (gene name)
Systematic name
D-glucose-6-phosphate phosphate-lyase (2-deoxy-L-scyllo-inosose-forming)
Comment
Requires Co2+ [2]. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Requires an NAD+ cofactor, which is transiently reduced during the reaction [1,4]. The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5′-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex [6,7].
History
created 2012
EC Tree
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003