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EC 1.14.99.40 Details
EC number
1.14.99.40
Accepted name
5,6-dimethylbenzimidazole synthase
Reaction
FMNH2 + NADH + H+ + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + other product
Other name(s)
BluB
Systematic name
FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming)
Comment
The C-2 of 5,6-dimethylbenzimidazole is derived from C-1′ of the ribityl group of FMNH2 and 2-H from the ribityl 1′-pro-S hydrogen. The other product may be barbituric acid. For a possible mechanism click here. The stoichiometery of the reaction is not known.
History
created 2010, deleted 2014
EC Tree
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003