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EC 1.1.3.28 Details
EC number
1.1.3.28
Accepted name
nucleoside oxidase
Reaction
inosine + O2 = 9-riburonosylhypoxanthine + H2O;; (1a) 2 inosine + O2 = 2 5′-dehydroinosine + 2 H2O;;(1b) 2 5′-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine
Systematic name
nucleoside:oxygen 5′-oxidoreductase
CAS registry number
82599-71-1
Comment
Other purine and pyrimidine nucleosides (as well as 2′-deoxyribonucleosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5′-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.39, nucleoside oxidase (H2O2-forming), as it produces water rather than hydrogen peroxide.
History
created 1992, modified 2001
EC Tree
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003