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EC 5.3.1.28 Details
show Brenda entryEC number
5.3.1.28
Accepted name
D-sedoheptulose-7-phosphate isomerase
Reaction
D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate
Other name(s)
sedoheptulose-7-phosphate isomerase,
phosphoheptose isomerase,
gmhA (gene name),
lpcA (gene name)
Systematic name
D-glycero-D-manno-heptose 7-phosphate aldose-ketose-isomerase
Comment
In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein.
History
created 2010
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
