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EC 3.5.1.121 Details
EC number
3.5.1.121
Accepted name
protein N-terminal asparagine amidohydrolase
Reaction
N-terminal L-asparaginyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + NH3
Other name(s)
NTAN1 (gene name)
Systematic name
protein N-terminal asparagine amidohydrolase
Comment
This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn. Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to L-aspartate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
History
created 2016
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