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EC 3.5.1.96 Details
EC number
3.5.1.96
Accepted name
succinylglutamate desuccinylase
Reaction
N-succinyl-L-glutamate + H2O = succinate + L-glutamate
Other name(s)
N2-succinylglutamate desuccinylase,
SGDS,
AstE
Systematic name
N-succinyl-L-glutamate amidohydrolase
CAS registry number
99676-40-1
Comment
Requires Co2+ for maximal activity [1]. N2-Acetylglutamate is not a substrate. This is the final enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase).
History
created 2006
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