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EC 1.8.1.14 Details
EC number
1.8.1.14
Accepted name
CoA-disulfide reductase
Reaction
2 CoA + NADP+ = CoA-disulfide + NADPH + H+
Other name(s)
CoA-disulfide reductase (NADH2), NADH2:CoA-disulfide oxidoreductase, CoA:NAD+ oxidoreductase (misleading), CoADR, coenzyme A disulfide reductase
Systematic name
CoA:NADP+ oxidoreductase
CAS registry number
206770-55-0
Comment
A flavoprotein. Not identical with EC 1.8.1.6 (cystine reductase), EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.13 (bis-γ-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [3], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [1].
History
created 1992 as EC 1.6.4.10, transferred 2002 to EC 1.8.1.14, modified 2005, modified 2013
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