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EC 3.4.13.23 Details
EC number
3.4.13.23
Accepted name
cysteinylglycine-S-conjugate dipeptidase
Reaction
an [L-cysteinylglycine]-S-conjugate + H2O = an L-cysteine-S-conjugate + glycine
Other name(s)
tpdA (gene name), LAP3 (gene name)
Systematic name
cysteinylglycine-S-conjugate dipeptide hydrolase
Comment
The enzyme participates in a widespread glutathione-mediated detoxification pathway. In animals the activity is usually catalysed by enzymes that have numerous additional activities, such as EC 3.4.11.1, leucyl aminopeptidase, EC 3.4.11.2, membrane alanyl aminopeptidase, and EC 3.4.13.19, membrane dipeptidase. However, in the bacterium Corynebacterium sp. Ax20, which degrades axillary secretions, the enzyme appears to be specific for this task.
History
created 2019
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