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EC 3.4.13.23 Details
show Brenda entryEC number
3.4.13.23
Accepted name
cysteinylglycine-S-conjugate dipeptidase
Reaction
an [L-cysteinylglycine]-S-conjugate + H2O = an L-cysteine-S-conjugate + glycine
Other name(s)
tpdA (gene name),
LAP3 (gene name)
Systematic name
cysteinylglycine-S-conjugate dipeptide hydrolase
Comment
The enzyme participates in a widespread glutathione-mediated detoxification pathway. In animals the activity is usually catalysed by enzymes that have numerous additional activities, such as EC 3.4.11.1, leucyl aminopeptidase, EC 3.4.11.2, membrane alanyl aminopeptidase, and EC 3.4.13.19, membrane dipeptidase. However, in the bacterium Corynebacterium sp. Ax20, which degrades axillary secretions, the enzyme appears to be specific for this task.
History
created 2019
back to topEC Tree
1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002
