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EC 4.1.3.39 Details
show Brenda entryEC number
4.1.3.39
Accepted name
4-hydroxy-2-oxovalerate aldolase
Reaction
(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate
Other name(s)
4-hydroxy-2-ketovalerate aldolase,
HOA,
DmpG,
4-hydroxy-2-oxovalerate pyruvate-lyase,
4-hydroxy-2-oxopentanoate pyruvate-lyase,
BphI,
4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
Systematic name
(S)-4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
CAS registry number
37325-52-3
Comment
Requires Mn2+ for maximal activity [1]. The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH [1]. In some bacterial species the enzyme forms a bifunctional complex with EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase [4,5].
History
created 2006, modified 2011
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002
