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EC 1.8.1.12 Details
EC number
1.8.1.12
Accepted name
trypanothione-disulfide reductase
Reaction
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+
Other name(s)
trypanothione reductase, NADPH2:trypanothione oxidoreductase
Systematic name
trypanothione:NADP+ oxidoreductase
CAS registry number
102210-35-5
Comment
Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre. (cf. EC 1.8.1.7, glutathione-disulfide reductase)
History
created 1989 as EC 1.6.4.8, transferred 2002 to EC 1.8.1.12
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