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EC 3.2.1.169 Details
show Brenda entryEC number
3.2.1.169
Accepted name
protein O-GlcNAcase
Reaction
(1) [protein]-3-O-(N-acetyl-β-D-glucosaminyl)-L-serine + H2O = [protein]-L-serine + N-acetyl-D-glucosamine ;; (2) [protein]-3-O-(N-acetyl-β-D-glucosaminyl)-L-theronine + H2O = [protein]-L-threonine + N-acetyl-D-glucosamine
Other name(s)
OGA,
glycoside hydrolase O-GlcNAcase,
O-GlcNAcase,
BtGH84,
O-GlcNAc hydrolase
Systematic name
[protein]-3-O-(N-acetyl-β-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase
Comment
Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins.
History
created 2011
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.7.2.1 nitrite reductase (NO-forming)
