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EC 1.6.2.4 Details

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EC number

1.6.2.4

Accepted name

NADPH—hemoprotein reductase

Reaction

NADPH + H⁺ + n oxidized hemoprotein = NADP⁺ + n reduced hemoprotein

Other name(s)

CPR, FAD-cytochrome c reductase, NADP-cytochrome c reductase, NADP-cytochrome reductase, NADPH-dependent cytochrome c reductase, NADPH:P-450 reductase, NADPH:ferrihemoprotein oxidoreductase, NADPH—cytochrome P-450 oxidoreductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH—cytochrome p-450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, TPNH₂ cytochrome c reductase, TPNH-cytochrome c reductase, aldehyde reductase (NADPH-dependent), cytochrome P-450 reductase, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, ferrihemoprotein P-450 reductase, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)

Systematic name

NADPH:hemoprotein oxidoreductase

CAS registry number

9023-03-4

Comment

A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases (e.g. EC 1.14.14.1, unspecific monooxygenase) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. It also reduces cytochrome b₅ and cytochrome c. The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.

History

created 1972, modified 2003

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.7.1 With NAD⁺ or NADP⁺ as acceptor

1.7.1.1 nitrate reductase (NADH)

1.7.1.2 nitrate reductase [NAD(P)H]

1.7.1.3 nitrate reductase (NADPH)

1.7.1.4 nitrite reductase [NAD(P)H]

1.7.1.5 hyponitrite reductase

1.7.1.6 azobenzene reductase

1.7.1.7 GMP reductase

1.7.1.8 created 2002, deleted 2002

1.7.1.9 nitroquinoline-N-oxide reductase

1.7.1.10 hydroxylamine reductase (NADH)

1.7.1.11 4-(dimethylamino)phenylazoxybenzene reductase

1.7.1.12 N-hydroxy-2-acetamidofluorene reductase

1.7.1.13 preQ₁ synthase

1.7.1.14 nitric oxide reductase [NAD(P)⁺, nitrous oxide-forming]

1.7.1.15 nitrite reductase (NADH)

1.7.1.16 nitrobenzene nitroreductase

1.7.1.17 FMN-dependent NADH-azoreductase

1.7.2 With a cytochrome as acceptor

1.7.3 With oxygen as acceptor

1.7.5 With a quinone or similar compound as acceptor

1.7.6 With a nitrogenous group as acceptor

1.7.7 With an iron-sulfur protein as acceptor

1.7.9 With a copper protein as acceptor

1.7.99 With unknown physiological acceptors

1.8 Acting on a sulfur group of donors

1.8.1 With NAD⁺ or NADP⁺ as acceptor

1.8.2 With a cytochrome as acceptor

1.8.3 With oxygen as acceptor

1.8.4 With a disulfide as acceptor

1.8.5 With a quinone or similar compound as acceptor

1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

1.8.7 With an iron-sulfur protein as acceptor

1.8.98 With other, known, physiological acceptors

1.8.99 With unknown physiological acceptors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)