EC Explorer

3.5.1.96

succinylglutamate desuccinylase

N-succinyl-L-glutamate + H₂O = succinate + L-glutamate

N²-succinylglutamate desuccinylase, SGDS, AstE

N-succinyl-L-glutamate amidohydrolase

99676-40-1

Requires Co²⁺ for maximal activity [1]. N²-Acetylglutamate is not a substrate. This is the final enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase).

created 2006