Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

EC 4.1.2.52 Details
EC number
4.1.2.52
Accepted name
4-hydroxy-2-oxoheptanedioate aldolase
Reaction
4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde
Other name(s)
2,4-dihydroxyhept-2-enedioate aldolase, HHED aldolase, 4-hydroxy-2-ketoheptanedioate aldolase, HKHD aldolase, HpcH, HpaI, 4-hydroxy-2-oxoheptanedioate succinate semialdehyde lyase (pyruvate-forming)
Systematic name
4-hydroxy-2-oxoheptanedioate succinate-semialdehyde-lyase (pyruvate-forming)
Comment
Requires Co2+ or Mn2+ for activity. The enzyme is also able to catalyse the aldol cleavage of 4-hydroxy-2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency. In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate. The enzyme from the bacterium Escherichia coli produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate [4].
History
created 2013
EC Tree
1.8.1.1 created 1961, deleted 1972