EC Explorer
[browse EC tree] - [search]
EC 1.16.3.1 Details
show Brenda entryEC number
1.16.3.1
Accepted name
ferroxidase
Reaction
4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O
Other name(s)
ceruloplasmin,
caeruloplasmin,
ferroxidase I,
iron oxidase,
iron(II):oxygen oxidoreductase,
ferro:O2 oxidoreductase,
iron II:oxygen oxidoreductase,
hephaestin,
HEPH
Systematic name
Fe(II):oxygen oxidoreductase
CAS registry number
9031-37-2, 104404-69-5
Comment
The enzyme in blood plasma (ceruloplasmin) belongs to the family of multicopper oxidases. In humans it accounts for 95% of plasma copper. It oxidizes Fe(II) to Fe(III), which allows the subsequent incorporation of the latter into proteins such as apotransferrin and lactoferrin. An enzyme from iron oxidizing bacterium strain TI-1 contains heme a.
History
created 1972, modified 2011
back to topEC Tree
1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002
