EC Explorer

EC 1.8.4.11 Details
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EC number
1.8.4.11
Accepted name
peptide-methionine (S)-S-oxide reductase
Reaction
(1) peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin;; (2) L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin
Other name(s)
MsrA, methionine sulfoxide reductase (ambiguous), methionine sulphoxide reductase A, methionine S-oxide reductase (ambiguous), methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase A, peptide methionine sulfoxide reductase
Systematic name
peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming]
Comment
The reaction occurs in the reverse direction to that shown above. The enzyme exhibits high specificity for the reduction of the S-form of L-methionine S-oxide, acting faster on the residue in a peptide than on the free amino acid [9]. On the free amino acid, it can also reduce D-methionine (S)-S-oxide but more slowly [9]. The enzyme plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged. In some species, e.g. Neisseria meningitidis, both this enzyme and EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, are found within the same protein whereas, in other species, they are separate proteins [1,4]. The reaction proceeds via a sulfenic-acid intermediate [5,10].
History
created 2006
EC Browser
1 Oxidoreductases (9651 organisms) download 3869963 sequences with EC number 1 in fasta format download 3869963 sequences with EC number 1 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 1) as tabstop separated file
1.21.1. undefined (18 organisms)
2 Transferases (6622 organisms) download 6047191 sequences with EC number 2 in fasta format download 6047191 sequences with EC number 2 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 2) as tabstop separated file
3 Hydrolases (10604 organisms) download 3219244 sequences with EC number 3 in fasta format download 3219244 sequences with EC number 3 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 3) as tabstop separated file
4 Lyases (5111 organisms) download 1852335 sequences with EC number 4 in fasta format download 1852335 sequences with EC number 4 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 4) as tabstop separated file
5 Isomerases (2083 organisms) download 1146532 sequences with EC number 5 in fasta format download 1146532 sequences with EC number 5 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 5) as tabstop separated file
6 Ligases (1547 organisms) download 1713431 sequences with EC number 6 in fasta format download 1713431 sequences with EC number 6 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 6) as tabstop separated file
7 Translocases (966 organisms) download 592568 sequences with EC number 7 in fasta format download 592568 sequences with EC number 7 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 7) as tabstop separated file