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EC 1.7.3.3 Details
EC number
1.7.3.3
Accepted name
factor-independent urate hydroxylase
Reaction
urate + O2 + H2O = 5-hydroxyisourate + H2O2
Other name(s)
uric acid oxidase, uricase, uricase II, urate oxidase
Systematic name
urate:oxygen oxidoreductase
CAS registry number
9002-12-4
Comment
This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC 3.5.2.17, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC 1.14.13.113 (FAD-dependent urate hydroxylase).
History
created 1961, modified 2002, modified 2005, modified 2010
EC Tree
1.8.1.1 created 1961, deleted 1972