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EC 3.1.11.8 Details
EC number
3.1.11.8
Accepted name
guanosine-5′-diphospho-5′-[DNA] diphosphatase
Reaction
guanosine-5′-diphospho-5′-[DNA] + H2O = phospho-5′-[DNA] + GMP
Other name(s)
aprataxin, pp5′G5′DNA diphosphatase, pp5′G5′-DNA guanylate hydrolase, APTX (gene name), HNT3 (gene name)
Systematic name
guanosine-5′-diphospho-5′-[DNA] hydrolase (guanosine 5′-phosphate-forming)
Comment
Aprataxin is a DNA-binding protein that catalyses (among other activities) the 5′ decapping of Gpp-DNA (formed by homologs of RtcB3 from the bacterium Myxococcus xanthus). The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and eventual release. The enzyme forms a 5′-phospho terminus that can be efficiently joined by "classical" ligases. The enzyme also possesses the activitiy of EC 3.1.11.7, adenosine-5′-diphospho-5′-[DNA] diphosphatase and EC 3.1.12.2, DNA-3′-diphospho-5′-guanosine diphosphatase.
History
created 2017, deleted 2019
EC Tree
1.1.1.68 created 1965, deleted 1978 [transferred to EC 1.1.99.15, deleted 1980]
1.1.1.70 created 1965, deleted 1978
1.1.1.74 created 1972, deleted 1976
1.1.1.89 created 1972, deleted 1976
1.1.1.109 created 1972, deleted 1976
1.1.1.139 created 1972, deleted 1978
1.1.1.155 created 1976, deleted 2004
1.1.1.171 created 1978, deleted 1984
1.1.1.180 created 1983, deleted 1984
1.1.1.182 created 1983, deleted 1990
1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004
1.1.1.242 created 1992, deleted 2001
1.1.1.249 provisional version created 1999, deleted 1999 (reinstated 2001 as EC 2.5.1.46)
1.1.1.253 created 1999, deleted 2003