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EC 1.1.1.62 Details
EC number
1.1.1.62
Accepted name
17β-estradiol 17-dehydrogenase
Reaction
17β-estradiol + NAD(P)+ = estrone + NAD(P)H + H+
Other name(s)
20α-hydroxysteroid dehydrogenase, 17β,20α-hydroxysteroid dehydrogenase, 17β-estradiol dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, 17β-HSD, HSD17B7
Systematic name
17β-estradiol:NAD(P)+ 17-oxidoreductase
CAS registry number
9028-61-9
Comment
The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.270, 3β-hydroxysteroid 3-dehydrogenase [3]. The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, 20α-hydroxysteroid dehydrogenase, it is Si-specific with respect to NAD(P)+.
History
created 1965, modified 1983, modified 1986, modified 2012
EC Tree
1.1.1.68 created 1965, deleted 1978 [transferred to EC 1.1.99.15, deleted 1980]
1.1.1.70 created 1965, deleted 1978
1.1.1.74 created 1972, deleted 1976
1.1.1.89 created 1972, deleted 1976
1.1.1.109 created 1972, deleted 1976
1.1.1.139 created 1972, deleted 1978
1.1.1.155 created 1976, deleted 2004
1.1.1.171 created 1978, deleted 1984
1.1.1.180 created 1983, deleted 1984
1.1.1.182 created 1983, deleted 1990
1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004
1.1.1.242 created 1992, deleted 2001
1.1.1.249 provisional version created 1999, deleted 1999 (reinstated 2001 as EC 2.5.1.46)
1.1.1.253 created 1999, deleted 2003