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EC 2.1.3.10 Details
EC number
2.1.3.10
Accepted name
malonyl-S-ACP:biotin-protein carboxyltransferase
Reaction
a malonyl-[acyl-carrier protein] + a biotinyl-[protein] = an acetyl-[acyl-carrier protein] + a carboxybiotinyl-[protein]
Other name(s)
malonyl-S-acyl-carrier protein:biotin-protein carboxyltransferase, MadC/MadD, MadC,D, malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxyltransferase
Systematic name
malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxytransferase
Comment
Derived from the components MadC and MadD of the anaerobic bacterium Malonomonas rubra, this enzyme is a component of EC 7.2.4.4, biotin-dependent malonate decarboxylase. The carboxy group is transferred from malonate to the prosthetic group of the biotin protein (MadF) with retention of configuration [2]. Similar to EC 4.1.1.87, malonyl-S-ACP decarboxylase, which forms part of the biotin-independent malonate decarboxylase (EC 4.1.1.88), this enzyme also follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetyl-[acyl-carrier protein] [3].
History
created 2008, modified 2018
EC Tree
1.1.5.1 created 1983, deleted 2002