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EC 4.2.1.136 Details

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EC number

4.2.1.136

Accepted name

ADP-dependent NAD(P)H-hydrate dehydratase

Reaction

(1) ADP + (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = AMP + phosphate + NADH;;(2) ADP + (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = AMP + phosphate + NADPH

Other name(s)

(6S)-β-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing), (6S)-6-β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing, NADH-forming)

Systematic name

(6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming)

Comment

Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers. The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (cf. EC 5.1.99.6), while the other catalyses the dehydration. Hence the enzyme can restore the complete mixture of isomers into NAD(P)H. The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf. EC 4.2.1.93, ATP-dependent NAD(P)H-hydrate dehydratase).

History

created 2012

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.98.1 alcohol dehydrogenase (azurin)

1.1.98.2 glucose-6-phosphate dehydrogenase (coenzyme-F₄₂₀)

1.1.98.3 decaprenylphospho-β-D-ribofuranose 2-dehydrogenase

1.1.98.4 F₄₂₀H₂:quinone oxidoreductase

1.1.98.5 secondary-alcohol dehydrogenase (coenzyme-F₄₂₀)

1.1.98.6 ribonucleoside-triphosphate reductase (formate)

1.1.98.7 serine-type anaerobic sulfatase-maturating enzyme

1.1.99 With unknown physiological acceptors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

1.5.1.2 pyrroline-5-carboxylate reductase

1.5.1.3 dihydrofolate reductase

1.5.1.4 created 1961, deleted 1976

1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP⁺)

1.5.1.6 formyltetrahydrofolate dehydrogenase

1.5.1.7 saccharopine dehydrogenase (NAD⁺, L-lysine-forming)

1.5.1.8 saccharopine dehydrogenase (NADP⁺, L-lysine-forming)

1.5.1.9 saccharopine dehydrogenase (NAD⁺, L-glutamate-forming)

1.5.1.10 saccharopine dehydrogenase (NADP⁺, L-glutamate-forming)

1.5.1.11 D-octopine dehydrogenase

1.5.1.12 1-pyrroline-5-carboxylate dehydrogenase

1.5.1.13 created 1972, deleted 2004

1.5.1.14 created 1976, deleted 1989

1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD⁺)

1.5.1.16 D-lysopine dehydrogenase

1.5.1.17 alanopine dehydrogenase

1.5.1.18 ephedrine dehydrogenase

1.5.1.19 D-nopaline dehydrogenase

1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

1.5.1.22 strombine dehydrogenase

1.5.1.23 tauropine dehydrogenase

1.5.1.24 N⁵-(carboxyethyl)ornithine synthase

1.5.1.25 thiomorpholine-carboxylate dehydrogenase

1.5.1.26 β-alanopine dehydrogenase

1.5.1.27 1,2-dehydroreticulinium reductase (NADPH)

1.5.1.28 opine dehydrogenase

1.5.1.29 FMN reductase [NAD(P)H]

1.5.1.30 flavin reductase (NADPH)

1.5.1.31 berberine reductase

1.5.1.32 vomilenine reductase

1.5.1.33 pteridine reductase

1.5.1.34 6,7-dihydropteridine reductase

1.5.1.35 1-pyrroline dehydrogenase

1.5.1.36 flavin reductase (NADH)

1.5.1.37 FAD reductase (NADH)

1.5.1.38 FMN reductase (NADPH)

1.5.1.39 FMN reductase [NAD(P)H]

1.5.1.40 8-hydroxy-5-deazaflavin:NADPH oxidoreductase

1.5.1.41 riboflavin reductase [NAD(P)H]

1.5.1.42 FMN reductase (NADH)

1.5.1.43 carboxynorspermidine synthase

1.5.1.44 festuclavine dehydrogenase

1.5.1.45 FAD reductase [NAD(P)H]

1.5.1.46 agroclavine dehydrogenase

1.5.1.47 dihydromethanopterin reductase [NAD(P)⁺]

1.5.1.48 2-methyl-1-pyrroline reductase

1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]

1.5.1.50 dihydromonapterin reductase

1.5.1.51 N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase

1.5.1.52 staphylopine dehydrogenase

1.5.1.53 methylenetetrahydrofolate reductase (NADPH)

1.5.1.54 methylenetetrahydrofolate reductase (NADH)

1.5.3 With oxygen as acceptor

1.5.4 With a disulfide as acceptor

1.5.5 With a quinone or similar compound as acceptor

1.5.7 With an iron-sulfur protein as acceptor

1.5.8 With a flavin or flavoprotein as acceptor

1.5.98 With other, known, physiological acceptors

1.5.99 With unknown physiological acceptors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)