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EC 2.7.7.97 Details
EC number
2.7.7.97
Accepted name
3-hydroxy-4-methylanthranilate adenylyltransferase
Reaction
ATP + 3-hydroxy-4-methylanthranilate = diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
Other name(s)
acmA (gene name),
sibE (gene name),
actinomycin synthase I,
4-MHA-activating enzyme,
ACMS I,
actinomycin synthetase I,
4-MHA pentapeptide lactone synthase AcmA
Systematic name
ATP:3-hydroxy-4-methylanthranilate adenylyltransferase
Comment
The enzyme, characterized from the bacteria Streptomyces anulatus and Streptosporangium sibiricum, activates 3-hydroxy-4-methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein.
History
created 2016
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