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EC 2.3.3.17 Details
EC number
2.3.3.17
Accepted name
methylthioalkylmalate synthase
Reaction
an ω-(methylsulfanyl)-2-oxoalkanoate + acetyl-CoA + H2O = a 2-[ω-(methylsulfanyl)alkyl]malate + CoA
Other name(s)
MAM1 (gene name), MAM3 (gene name), acetyl-CoA:ω-(methylthio)-2-oxoalkanoate C-acetyltransferase
Systematic name
acetyl-CoA:ω-(methylsulfanyl)-2-oxoalkanoate C-acetyltransferase
Comment
The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. Two forms are known - MAM1 catalyses only only the first two rounds of methionine chain elongation, while MAM3 catalyses all six cycles, up to formation of L-hexahomomethionine.
History
created 2016
EC Tree
1.1.5.1 created 1983, deleted 2002