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EC 4.1.2.51 Details
EC number
4.1.2.51
Accepted name
2-dehydro-3-deoxy-D-gluconate aldolase
Reaction
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
Other name(s)
Pto1279 (gene name), KDGA, KDG-specific aldolase
Systematic name
2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-lyase (pyruvate-forming)
Comment
The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. In the direction of aldol synthesis the enzyme catalyses the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate at a similar ratio. It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase.
History
created 2013
EC Tree
1.1.5.1 created 1983, deleted 2002