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EC 3.5.4.38 Details
EC number
3.5.4.38
Accepted name
single-stranded DNA cytosine deaminase
Reaction
cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3
Other name(s)
AID, activation-induced deaminase, AICDA (gene name), activation-induced cytidine deaminase
Systematic name
single-stranded DNA cytosine aminohydrolase
Comment
The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) [2]. The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
History
created 2013
EC Tree
1.1.1.68 created 1965, deleted 1978 [transferred to EC 1.1.99.15, deleted 1980]
1.1.1.70 created 1965, deleted 1978
1.1.1.74 created 1972, deleted 1976
1.1.1.89 created 1972, deleted 1976
1.1.1.109 created 1972, deleted 1976
1.1.1.139 created 1972, deleted 1978
1.1.1.155 created 1976, deleted 2004
1.1.1.171 created 1978, deleted 1984
1.1.1.180 created 1983, deleted 1984
1.1.1.182 created 1983, deleted 1990
1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004
1.1.1.242 created 1992, deleted 2001
1.1.1.249 provisional version created 1999, deleted 1999 (reinstated 2001 as EC 2.5.1.46)
1.1.1.253 created 1999, deleted 2003