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EC 2.7.7.86 Details
show Brenda entryEC number
2.7.7.86
Accepted name
cyclic GMP-AMP synthase
Reaction
ATP + GTP = 2 diphosphate + cyclic Gp(2′-5′)Ap(3′-5′) (overall reaction);;(1a) ATP + GTP = pppGp(2′-5′)A + diphosphate;;(1b) pppGp(2′-5′)A = cyclic Gp(2′-5′)Ap(3′-5′) + diphosphate
Other name(s)
cGAMP synthase,
cGAS
Systematic name
ATP:GTP adenylyltransferase (cyclizing)
Comment
Cyclic Gp(2′-5′)Ap(3′-5′) is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
History
created 2013, modified 2014
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002
