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EC 1.11.2.1 Details
EC number
1.11.2.1
Accepted name
unspecific peroxygenase
Reaction
RH + H2O2 = ROH + H2O
Other name(s)
aromatic peroxygenase, mushroom peroxygenase, haloperoxidase-peroxygenase, Agrocybe aegerita peroxidase
Systematic name
substrate:hydrogen-peroxide oxidoreductase (RH-hydroxylating or -epoxidising)
Comment
A heme-thiolate protein (P-450). Enzymes of this type include glycoproteins secreted by agaric basidiomycetes. They catalyse the insertion of an oxygen atom from H2O2 into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane. Reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations. They have little or no activity toward chloride. Mechanistically, the catalytic cycle of unspecific (mono)-peroxygenases combines elements of the "shunt" pathway of cytochrome P-450s (a side activity that utilizes a peroxide in place of dioxygen and NAD[P]H) and the classic heme peroxidase cycle.
History
created 2011
EC Tree
1.1.3.1 created 1961, deleted 1984
1.1.3.22 created 1961 as EC 1.2.3.2, transferred 1984 to EC 1.1.3.22, modified 1989, deleted 2004
1.1.3.25 created 1986, deleted 2005
1.1.3.26 created 1989, deleted 2002
1.1.3.31 created 1992, deleted 2003
1.1.3.32 created 1999, deleted 2002
1.1.3.33 created 1999, deleted 2002
1.1.3.34 created 1999, deleted 2002
1.1.3.35 created 1999, deleted 2002
1.1.3.36 created 1999, deleted 2002