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EC 3.2.2.27 Details
show Brenda entryEC number
3.2.2.27
Accepted name
uracil-DNA glycosylase
Reaction
Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil
Other name(s)
UdgB (ambiguous),
uracil-DNA N-glycosylase,
UDG (ambiguous),
uracil DNA glycohydrolase
Systematic name
uracil-DNA deoxyribohydrolase (uracil-releasing)
Comment
Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. EC 3.2.2.27 and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA.
History
created 2009
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1 Oxidoreductases
3 Hydrolases
3.6.4.1 myosin ATPase
