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EC 2.4.99.12 Details
EC number
2.4.99.12
Accepted name
lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
Reaction
CMP-β-Kdo + a lipid IVA + CMP-β-Kdo = CMP + an α-Kdo-(2→6)-[lipid IVA]
Other name(s)
waaA (gene name), kdtA (gene name), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase, lipid IVA KDO transferase, CMP-3-deoxy-D-manno-oct-2-ulosonate:lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase, KDO transferase
Systematic name
CMP-3-deoxy-β-D-manno-oct-2-ulosonate:[lipid IVA] 3-deoxy-D-manno-oct-2-ulosonate transferase (configuration-inverting)
Comment
The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.13 [(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The monofunctional enzymes from Bordetella pertusis, Aquifex aeolicus and Haemophilus influenzae catalyse the transfer of a single 3-deoxy-D-manno-oct-2-ulosonate residue from CMP-3-deoxy-D-manno-oct-2-ulosonate to lipid IVA [2-4]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [5].
History
created 2010, modified 2011
EC Tree
3.6.1.4 created 1961, deleted 1965
3.6.1.32 created 1984, deleted 2000
3.6.1.33 created 1984, deleted 2000
3.6.1.34 created 1984, deleted 2000
3.6.1.35 created 1984, deleted 2000
3.6.1.36 created 1984, deleted 2000
3.6.1.37 created 1984, deleted 2000
3.6.1.38 created 1984, deleted 2000
3.6.1.46 created 2000, deleted 2003
3.6.1.47 created 2000, deleted 2003
3.6.1.48 created 2000, deleted 200
3.6.1.49 created 2000, deleted 2003
3.6.1.50 created 2000, deleted 2003
3.6.1.51 created 2000, deleted 2003
3.6.3.13 created 2000, deleted 2001