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EC 3.6.1.23 Details
EC number
3.6.1.23
Accepted name
dUTP diphosphatase
Reaction
dUTP + H2O = dUMP + diphosphate
Other name(s)
DUT (gene name), deoxyuridine-triphosphatase, dUTPase, dUTP pyrophosphatase, desoxyuridine 5′-triphosphate nucleotidohydrolase, desoxyuridine 5′-triphosphatase
Systematic name
dUTP nucleotidohydrolase
CAS registry number
37289-34-2
Comment
The enzyme catalyses the Mg2+-dependent hydrolysis of dUTP to dUMP, providing the substrate for EC 2.1.1.45, thymidylate synthase, leading to production of thymidine nucleotides. By reducing the effective ratio of dUTP to TTP, the enzyme also reduces the possibility of dUTP incorporation into DNA.
History
created 1972
EC Tree
3.6.1.4 created 1961, deleted 1965
3.6.1.32 created 1984, deleted 2000
3.6.1.33 created 1984, deleted 2000
3.6.1.34 created 1984, deleted 2000
3.6.1.35 created 1984, deleted 2000
3.6.1.36 created 1984, deleted 2000
3.6.1.37 created 1984, deleted 2000
3.6.1.38 created 1984, deleted 2000
3.6.1.46 created 2000, deleted 2003
3.6.1.47 created 2000, deleted 2003
3.6.1.48 created 2000, deleted 200
3.6.1.49 created 2000, deleted 2003
3.6.1.50 created 2000, deleted 2003
3.6.1.51 created 2000, deleted 2003