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EC 1.4.3.21 Details
EC number
1.4.3.21
Accepted name
primary-amine oxidase
Reaction
RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2
Other name(s)
amine oxidase (ambiguous), amine oxidase (copper-containing), amine oxidase (pyridoxal containing) (incorrect), benzylamine oxidase (incorrect), CAO (ambiguous), copper amine oxidase (ambiguous), Cu-amine oxidase (ambiguous), Cu-containing amine oxidase (ambiguous), diamine oxidase (incorrect), diamino oxhydrase (incorrect), histamine deaminase (ambiguous), histamine oxidase (ambiguous), monoamine oxidase (ambiguous), plasma monoamine oxidase (ambiguous), polyamine oxidase (ambiguous), semicarbazide-sensitive amine oxidase (ambiguous), SSAO (ambiguous)
Systematic name
primary-amine:oxygen oxidoreductase (deaminating)
Comment
A group of enzymes that oxidize primary monoamines but have little or no activity towards diamines, such as histamine, or towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, monoamine oxidase, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. In some mammalian tissues the enzyme also functions as a vascular-adhesion protein (VAP-1).
History
created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)
EC Tree
3.6.1.4 created 1961, deleted 1965
3.6.1.32 created 1984, deleted 2000
3.6.1.33 created 1984, deleted 2000
3.6.1.34 created 1984, deleted 2000
3.6.1.35 created 1984, deleted 2000
3.6.1.36 created 1984, deleted 2000
3.6.1.37 created 1984, deleted 2000
3.6.1.38 created 1984, deleted 2000
3.6.1.46 created 2000, deleted 2003
3.6.1.47 created 2000, deleted 2003
3.6.1.48 created 2000, deleted 200
3.6.1.49 created 2000, deleted 2003
3.6.1.50 created 2000, deleted 2003
3.6.1.51 created 2000, deleted 2003