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EC 3.5.99.6 Details
EC number
3.5.99.6
Accepted name
glucosamine-6-phosphate deaminase
Reaction
α-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3
Other name(s)
glucosaminephosphate isomerase (ambiguous), glucosamine-6-phosphate isomerase (ambiguous), phosphoglucosaminisomerase (ambiguous), glucosamine phosphate deaminase, aminodeoxyglucosephosphate isomerase (ambiguous), phosphoglucosamine isomerase (ambiguous), 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
Systematic name
2-amino-2-deoxy-α-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
CAS registry number
9013-10-9
Comment
The enzyme uses ring opening and isomerization of the aldose-ketose type to convert the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
History
created 1961 as EC 5.3.1.10, transferred 2000 to EC 3.5.99.6
EC Tree
3.6.1.4 created 1961, deleted 1965
3.6.1.32 created 1984, deleted 2000
3.6.1.33 created 1984, deleted 2000
3.6.1.34 created 1984, deleted 2000
3.6.1.35 created 1984, deleted 2000
3.6.1.36 created 1984, deleted 2000
3.6.1.37 created 1984, deleted 2000
3.6.1.38 created 1984, deleted 2000
3.6.1.46 created 2000, deleted 2003
3.6.1.47 created 2000, deleted 2003
3.6.1.48 created 2000, deleted 200
3.6.1.49 created 2000, deleted 2003
3.6.1.50 created 2000, deleted 2003
3.6.1.51 created 2000, deleted 2003