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EC 3.6.1.5 Details
EC number
3.6.1.5
Accepted name
apyrase
Reaction
a nucleoside 5′-triphosphate + 2 H2O = a nucleoside 5′-phosphate + 2 phosphate (overall reaction);;(1a) a nucleoside 5′-triphosphate + H2O = a nucleoside 5′-diphosphate + phosphate;;(1b) a nucleoside 5′-diphosphate + H2O = a nucleoside 5′-phosphate + phosphate
Other name(s)
ATP-diphosphatase (ambiguous), adenosine diphosphatase, ADPase, ATP diphosphohydrolase [ambiguous]
Systematic name
nucleoside triphosphate phosphohydrolase (nucleoside monophosphoate-forming)
CAS registry number
9000-95-7
Comment
Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyse NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. They differ from ATPases, which specifically hydrolyse ATP, by hydrolysing both ATP and ADP. The eukaryotic enzymes requires Ca2+, but Mg2+ can substitute. Most of the ecto-ATPases that occur on the cell surface and hydrolyse extracellular nucleotides belong to this enzyme family.
History
created 1961, modified 1976, modified 2000, modified 2013
EC Tree
3.6.1.4 created 1961, deleted 1965
3.6.1.32 created 1984, deleted 2000
3.6.1.33 created 1984, deleted 2000
3.6.1.34 created 1984, deleted 2000
3.6.1.35 created 1984, deleted 2000
3.6.1.36 created 1984, deleted 2000
3.6.1.37 created 1984, deleted 2000
3.6.1.38 created 1984, deleted 2000
3.6.1.46 created 2000, deleted 2003
3.6.1.47 created 2000, deleted 2003
3.6.1.48 created 2000, deleted 200
3.6.1.49 created 2000, deleted 2003
3.6.1.50 created 2000, deleted 2003
3.6.1.51 created 2000, deleted 2003