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EC 2.3.1.293 Details
EC number
2.3.1.293
Accepted name
meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I
Reaction
an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + a holo-[acyl-carrier protein]
Other name(s)
kasA (gene name), β-ketoacyl-acyl carrier protein synthase KasA
Systematic name
ultra-long-chain mono-unsaturated fattyl acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)
Comment
The enzyme is part of the fatty acid synthase (FAS) II system of mycobacteria, which extends modified products of the FAS I system, eventually forming meromycolic acids that are incorporated into mycolic acids. Meromycolic acids consist of a long chain, typically 50-60 carbons, which is functionalized by different groups.Two 3-oxoacyl-(acyl carrier protein) synthases function within the FAS II system, encoded by the kasA and kasB genes. The two enzymes share some sequence identity but function independently on separate sets of substrates. KasA differs from KasB [EC 2.3.1.294, meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II], by preferring shorter (C-22 to C-36) and more saturated (only one double bond) substrates.
History
created 2019
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.1.1 carboxylesterase
3.1.1.2 arylesterase
3.1.1.3 triacylglycerol lipase
3.1.1.4 phospholipase A2
3.1.1.5 lysophospholipase
3.1.1.6 acetylesterase
3.1.1.7 acetylcholinesterase
3.1.1.8 cholinesterase
3.1.1.9 created 1961, deleted 1972
3.1.1.10 tropinesterase
3.1.1.11 pectinesterase
3.1.1.12 created 1961, deleted 1972
3.1.1.13 sterol esterase
3.1.1.14 chlorophyllase
3.1.1.15 L-arabinonolactonase
3.1.1.16 created 1961, deleted 1972
3.1.1.17 gluconolactonase
3.1.1.18 created 1961, deleted 1982
3.1.1.19 uronolactonase
3.1.1.20 tannase
3.1.1.21 retinyl-palmitate esterase
3.1.1.22 hydroxybutyrate-dimer hydrolase
3.1.1.23 acylglycerol lipase
3.1.1.24 3-oxoadipate enol-lactonase
3.1.1.25 1,4-lactonase
3.1.1.26 galactolipase
3.1.1.27 4-pyridoxolactonase
3.1.1.28 acylcarnitine hydrolase
3.1.1.29 aminoacyl-tRNA hydrolase
3.1.1.30 D-arabinonolactonase
3.1.1.31 6-phosphogluconolactonase
3.1.1.32 phospholipase A1
3.1.1.33 6-acetylglucose deacetylase
3.1.1.34 lipoprotein lipase
3.1.1.35 dihydrocoumarin hydrolase
3.1.1.36 limonin-D-ring-lactonase
3.1.1.37 steroid-lactonase
3.1.1.38 triacetate-lactonase
3.1.1.39 actinomycin lactonase
3.1.1.40 orsellinate-depside hydrolase
3.1.1.41 cephalosporin-C deacetylase
3.1.1.42 chlorogenate hydrolase
3.1.1.43 α-amino-acid esterase
3.1.1.44 4-methyloxaloacetate esterase
3.1.1.45 carboxymethylenebutenolidase
3.1.1.46 deoxylimonate A-ring-lactonase
3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase
3.1.1.48 fusarinine-C ornithinesterase
3.1.1.49 sinapine esterase
3.1.1.50 wax-ester hydrolase
3.1.1.51 phorbol-diester hydrolase
3.1.1.52 phosphatidylinositol deacylase
3.1.1.53 sialate O-acetylesterase
3.1.1.54 acetoxybutynylbithiophene deacetylase
3.1.1.55 acetylsalicylate deacetylase
3.1.1.56 methylumbelliferyl-acetate deacetylase
3.1.1.57 2-pyrone-4,6-dicarboxylate lactonase
3.1.1.58 N-acetylgalactosaminoglycan deacetylase
3.1.1.59 juvenile-hormone esterase
3.1.1.60 bis(2-ethylhexyl)phthalate esterase
3.1.1.61 protein-glutamate methylesterase
3.1.1.62 created 1989, deleted 1992
3.1.1.63 11-cis-retinyl-palmitate hydrolase
3.1.1.64 retinoid isomerohydrolase
3.1.1.65 L-rhamnono-1,4-lactonase
3.1.1.66 5-(3,4-diacetoxybut-1-ynyl)-2,2′-bithiophene deacetylase
3.1.1.67 fatty-acyl-ethyl-ester synthase
3.1.1.68 xylono-1,4-lactonase
3.1.1.69 created 1992, deleted 2002
3.1.1.70 cetraxate benzylesterase
3.1.1.71 acetylalkylglycerol acetylhydrolase
3.1.1.72 acetylxylan esterase
3.1.1.73 feruloyl esterase
3.1.1.74 cutinase
3.1.1.75 poly(3-hydroxybutyrate) depolymerase
3.1.1.76 poly(3-hydroxyoctanoate) depolymerase
3.1.1.77 acyloxyacyl hydrolase
3.1.1.78 polyneuridine-aldehyde esterase
3.1.1.79 hormone-sensitive lipase
3.1.1.80 acetylajmaline esterase
3.1.1.81 quorum-quenching N-acyl-homoserine lactonase
3.1.1.82 pheophorbidase
3.1.1.83 monoterpene ε-lactone hydrolase
3.1.1.84 cocaine esterase
3.1.1.85 pimelyl-[acyl-carrier protein] methyl ester esterase
3.1.1.86 rhamnogalacturonan acetylesterase
3.1.1.87 fumonisin B1 esterase
3.1.1.88 pyrethroid hydrolase
3.1.1.89 protein phosphatase methylesterase-1
3.1.1.90 all-trans-retinyl ester 13-cis isomerohydrolase
3.1.1.91 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase
3.1.1.92 4-sulfomuconolactone hydrolase
3.1.1.93 mycophenolic acid acyl-glucuronide esterase
3.1.1.94 versiconal hemiacetal acetate esterase
3.1.1.95 aclacinomycin methylesterase
3.1.1.96 D-aminoacyl-tRNA deacylase
3.1.1.97 methylated diphthine methylhydrolase
3.1.1.98 [Wnt protein] O-palmitoleoyl-L-serine hydrolase
3.1.1.99 6-deoxy-6-sulfogluconolactonase
3.1.1.100 chlorophyllide a hydrolase
3.1.1.101 poly(ethylene terephthalate) hydrolase
3.1.1.102 mono(ethylene terephthalate) hydrolase
3.1.1.103 teichoic acid D-alanine hydrolase
3.1.1.104 5-phospho-D-xylono-1,4-lactonase
3.1.1.105 3-O-acetylpapaveroxine carboxylesterase
3.1.1.106 O-acetyl-ADP-ribose deacetylase
3.1.1.107 apo-salmochelin esterase
3.1.1.108 iron(III)-enterobactin esterase
3.1.1.109 iron(III)-salmochelin esterase
3.1.1.110 xylono-1,5-lactonase
3.1.1.111 phosphatidylserine sn-1 acylhydrolase
3.1.1.112 isoamyl acetate esterase
3.1.1.113 ethyl acetate hydrolase
3.1.1.114 methyl acetate hydrolase
3.1.1.115 D-apionolactonase
3.1.1.116 sn-1-specific diacylglycerol lipase
3.1.1.117 (4-O-methyl)-D-glucuronate—lignin esterase
3.1.1.118 phospholipid sn-1 acylhydrolase
3.1.1.119 exo-acting protein-α-N-acetylgalactosaminidase
3.1.2 Thioester hydrolases
3.1.3 Phosphoric-monoester hydrolases
3.1.4 Phosphoric-diester hydrolases
3.1.5 Triphosphoric-monoester hydrolases
3.1.6 Sulfuric-ester hydrolases
3.1.7 Diphosphoric-monoester hydrolases
3.1.8 Phosphoric-triester hydrolases
3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters
3.1.12 Exodeoxyribonucleases producing 3′-phosphomonoesters
3.1.13 Exoribonucleases producing 5′-phosphomonoesters
3.1.14 Exoribonucleases producing 3'-phosphomonoesters
3.1.15 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters
3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters
3.1.23 Site-specific endodeoxyribonucleases: cleavage is sequence specific (deleted sub-subclass)
3.1.23.1 created 1978, deleted 1984
3.1.23.2 created 1978, deleted 1984
3.1.23.3 created 1978, deleted 1984
3.1.23.4 created 1978, deleted 1984
3.1.23.5 created 1978, deleted 1984
3.1.23.6 created 1978, deleted 1984
3.1.23.7 created 1978, deleted 1984
3.1.23.8 created 1978, deleted 1984
3.1.23.9 created 1978, deleted 1984
3.1.23.10 created 1978, deleted 1984
3.1.23.11 created 1978, deleted 1984
3.1.23.12 created 1978, modified 1982, deleted 1984
3.1.23.13 created 1978, deleted 1984
3.1.23.14 created 1978, deleted 1984
3.1.23.15 created 1978, deleted 1984
3.1.23.16 created 1978, deleted 1984
3.1.23.17 created 1978, deleted 1984
3.1.23.18 created 1978, deleted 1984
3.1.23.19 created 1978, deleted 1984
3.1.23.20 created 1978, deleted 1984
3.1.23.21 created 1978, deleted 1984
3.1.23.22 created 1978, deleted 1984
3.1.23.23 created 1978, deleted 1984
3.1.23.24 created 1978, deleted 1984
3.1.23.25 created 1978, deleted 1984
3.1.23.26 created 1978, deleted 1984
3.1.23.27 created 1978, deleted 1984
3.1.23.28 created 1978, deleted 1984
3.1.23.29 created 1978, deleted 1984
3.1.23.30 created 1978, modified 1982, deleted 1984
3.1.23.31 created 1978, deleted 1984
3.1.23.32 created 1978, modified 1982, deleted 1984
3.1.23.33 created 1978, deleted 1984
3.1.23.34 created 1978, deleted 1984
3.1.23.35 created 1978, deleted 1984
3.1.23.36 created 1978, deleted 1984
3.1.23.37 created 1978, deleted 1984
3.1.23.38 created 1978, deleted 1984
3.1.23.39 created 1978, deleted 1984
3.1.23.40 created 1978, deleted 1984
3.1.23.41 created 1978, deleted 1984
3.1.23.42 created 1978, deleted 1984
3.1.23.43 created 1978, modified 1982, deleted 1984
3.1.23.44 created 1978, deleted 1984
3.1.23.45 created 1978, modified 1982, deleted 1984
3.1.23.46 created 1982, deleted 1984
3.1.23.47 created 1982, deleted 1984
3.1.23.48 created 1982, deleted 1984
3.1.23.49 created 1982, deleted 1984
3.1.23.50 created 1982, deleted 1984
3.1.23.51 created 1982, deleted 1984
3.1.23.52 created 1982, deleted 1984
3.1.23.53 created 1982, deleted 1984
3.1.23.54 created 1982, deleted 1984
3.1.23.55 created 1982, deleted 1984
3.1.23.56 created 1982, deleted 1984
3.1.23.57 created 1982, deleted 1984
3.1.23.58 created 1982, deleted 1984
3.1.23.59 created 1982, deleted 1984
3.1.23.60 created 1982, deleted 1984
3.1.23.61 created 1982, deleted 1984
3.1.23.62 created 1982, deleted 1984
3.1.23.63 created 1982, deleted 1984
3.1.23.64 created 1982, deleted 1984
3.1.23.65 created 1982, deleted 1984
3.1.23.66 created 1982, deleted 1984
3.1.23.67 created 1982, deleted 1984
3.1.23.68 created 1982, deleted 1984
3.1.23.69 created 1982, deleted 1984
3.1.23.70 created 1982, deleted 1984
3.1.23.71 created 1982, deleted 1984
3.1.23.72 created 1982, deleted 1984
3.1.23.73 created 1982, deleted 1984
3.1.23.74 created 1982, deleted 1984
3.1.23.75 created 1982, deleted 1984
3.1.23.76 created 1982, deleted 1984
3.1.23.77 created 1982, deleted 1984
3.1.23.78 created 1982, deleted 1984
3.1.23.79 created 1982, deleted 1984
3.1.23.80 created 1982, deleted 1984
3.1.23.81 created 1982, deleted 1984
3.1.23.82 created 1982, deleted 1984
3.1.23.83 created 1982, deleted 1984
3.1.23.84 created 1982, deleted 1984
3.1.23.85 created 1982, deleted 1984
3.1.23.86 created 1982, deleted 1984
3.1.23.87 created 1982, deleted 1984
3.1.23.88 created 1982, deleted 1984
3.1.23.89 created 1982, deleted 1984
3.1.23.90 created 1982, deleted 1984
3.1.23.91 created 1982, deleted 1984
3.1.23.92 created 1982, deleted 1984
3.1.23.93 created 1982, deleted 1984
3.1.23.94 created 1982, deleted 1984
3.1.23.95 created 1982, deleted 1984
3.1.23.96 created 1982, deleted 1984
3.1.23.97 created 1982, deleted 1984
3.1.23.98 created 1982, deleted 1984
3.1.23.99 created 1982, deleted 1984
3.1.23.100 created 1982, deleted 1984
3.1.23.101 created 1982, deleted 1984
3.1.23.102 created 1982, deleted 1984
3.1.23.103 created 1982, deleted 1984
3.1.23.104 created 1982, deleted 1984
3.1.23.105 created 1982, deleted 1984
3.1.23.106 created 1982, deleted 1984
3.1.23.107 created 1982, deleted 1984
3.1.23.108 created 1982, deleted 1984
3.1.23.109 created 1982, deleted 1984
3.1.24 Site specific endodeoxyribonucleases: cleavage is not sequence specific (deleted sub-subclass)
3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases
3.1.26 Endoribonucleases producing 5'-phosphomonoesters
3.1.27 Endoribonucleases producing 3'-phosphomonoesters
3.1.30 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.31 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases