EC Explorer

2.1.1.354

[histone H3]-lysine⁴ N-trimethyltransferase

3 S-adenosyl-L-methionine + a [histone H3]-L-lysine⁴ = 3 S-adenosyl-L-homocysteine + a [histone H3]-N⁶,N⁶,N⁶-trimethyl-L-lysine⁴ (overall reaction);;(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine⁴ = S-adenosyl-L-homocysteine + a [histone H3]-N⁶-methyl-L-lysine⁴;;(1b) S-adenosyl-L-methionine + a [histone H3]-N⁶-methyl-L-lysine⁴ = S-adenosyl-L-homocysteine + a [histone H3]-N⁶,N⁶-dimethyl-L-lysine⁴;;(1c) S-adenosyl-L-methionine + a [histone H3]-N⁶,N⁶-dimethyl-L-lysine⁴ = S-adenosyl-L-homocysteine + a [histone H3]-N⁶,N⁶,N⁶-trimethyl-L-lysine⁴

KMT2H (gene name), KMT3C (gene name), KMT3D (gene name), KMT3E (gene name), PRDM9 (gene name), MLL5 (gene name), ASH1L (gene name), SMYD1 (gene name), SMYD2 (gene name), SMYD3 (gene name)

S-adenosyl-L-methionine:[histone H3]-L-lysine⁴ N⁶-trimethyltransferase

This entry describes several enzymes that successively methylate the L-lysine⁴ residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. EC 2.1.1.364, [histone H3]-lysine⁴ N-methyltransferase, describes enzymes that can catalyse only monomethylation of this substrate (the first sub-reaction of this entry); EC 2.1.1.370, [histone H3]-lysine⁴ N-dimethyltransferase, describes enzymes that catalyse only dimethylation of this substrate (the first two sub-reactions of this entry)

created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.354, modified 2020