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EC 1.14.14.32 Details
EC number
1.14.14.32
Accepted name
17α-hydroxyprogesterone deacetylase
Reaction
(1) 17α-hydroxyprogesterone + [reduced NADPH—hemoprotein reductase] + O2 = androstenedione + acetate + [oxidized NADPH—hemoprotein reductase] + H2O;;(2) 17α-hydroxypregnenolone + [reduced NADPH—hemoprotein reductase] + O2 = 3β-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
C-17/C-20 lyase, 17α-hydroxyprogesterone acetaldehyde-lyase, CYP17, CYP17A1 (gene name), 17α-hydroxyprogesterone 17,20-lyase
Systematic name
17α-hydroxyprogesterone,NADPH—hemoprotein reductase:oxygen oxidoreductase (17α-hydroxylating, acetate-releasing)
CAS registry number
62213-24-5
Comment
A microsomal cytochrome P-450 (heme-thiolate) protein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and 3β-hydroxyandrost-5-en-17-one, leading to sex hormone biosynthesis. The activity of this reaction is dependent on the allosteric interaction of the enzyme with cytochrome b5 without any transfer of electrons from the cytochrome [2,4]. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17α-hydroxyprogesterone and 17α-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter [1].
History
created 1976 as EC 4.1.2.30, transferred 2016 to EC 1.14.14.32
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.1.1 carboxylesterase
3.1.1.2 arylesterase
3.1.1.3 triacylglycerol lipase
3.1.1.4 phospholipase A2
3.1.1.5 lysophospholipase
3.1.1.6 acetylesterase
3.1.1.7 acetylcholinesterase
3.1.1.8 cholinesterase
3.1.1.9 created 1961, deleted 1972
3.1.1.10 tropinesterase
3.1.1.11 pectinesterase
3.1.1.12 created 1961, deleted 1972
3.1.1.13 sterol esterase
3.1.1.14 chlorophyllase
3.1.1.15 L-arabinonolactonase
3.1.1.16 created 1961, deleted 1972
3.1.1.17 gluconolactonase
3.1.1.18 created 1961, deleted 1982
3.1.1.19 uronolactonase
3.1.1.20 tannase
3.1.1.21 retinyl-palmitate esterase
3.1.1.22 hydroxybutyrate-dimer hydrolase
3.1.1.23 acylglycerol lipase
3.1.1.24 3-oxoadipate enol-lactonase
3.1.1.25 1,4-lactonase
3.1.1.26 galactolipase
3.1.1.27 4-pyridoxolactonase
3.1.1.28 acylcarnitine hydrolase
3.1.1.29 aminoacyl-tRNA hydrolase
3.1.1.30 D-arabinonolactonase
3.1.1.31 6-phosphogluconolactonase
3.1.1.32 phospholipase A1
3.1.1.33 6-acetylglucose deacetylase
3.1.1.34 lipoprotein lipase
3.1.1.35 dihydrocoumarin hydrolase
3.1.1.36 limonin-D-ring-lactonase
3.1.1.37 steroid-lactonase
3.1.1.38 triacetate-lactonase
3.1.1.39 actinomycin lactonase
3.1.1.40 orsellinate-depside hydrolase
3.1.1.41 cephalosporin-C deacetylase
3.1.1.42 chlorogenate hydrolase
3.1.1.43 α-amino-acid esterase
3.1.1.44 4-methyloxaloacetate esterase
3.1.1.45 carboxymethylenebutenolidase
3.1.1.46 deoxylimonate A-ring-lactonase
3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase
3.1.1.48 fusarinine-C ornithinesterase
3.1.1.49 sinapine esterase
3.1.1.50 wax-ester hydrolase
3.1.1.51 phorbol-diester hydrolase
3.1.1.52 phosphatidylinositol deacylase
3.1.1.53 sialate O-acetylesterase
3.1.1.54 acetoxybutynylbithiophene deacetylase
3.1.1.55 acetylsalicylate deacetylase
3.1.1.56 methylumbelliferyl-acetate deacetylase
3.1.1.57 2-pyrone-4,6-dicarboxylate lactonase
3.1.1.58 N-acetylgalactosaminoglycan deacetylase
3.1.1.59 juvenile-hormone esterase
3.1.1.60 bis(2-ethylhexyl)phthalate esterase
3.1.1.61 protein-glutamate methylesterase
3.1.1.62 created 1989, deleted 1992
3.1.1.63 11-cis-retinyl-palmitate hydrolase
3.1.1.64 retinoid isomerohydrolase
3.1.1.65 L-rhamnono-1,4-lactonase
3.1.1.66 5-(3,4-diacetoxybut-1-ynyl)-2,2′-bithiophene deacetylase
3.1.1.67 fatty-acyl-ethyl-ester synthase
3.1.1.68 xylono-1,4-lactonase
3.1.1.69 created 1992, deleted 2002
3.1.1.70 cetraxate benzylesterase
3.1.1.71 acetylalkylglycerol acetylhydrolase
3.1.1.72 acetylxylan esterase
3.1.1.73 feruloyl esterase
3.1.1.74 cutinase
3.1.1.75 poly(3-hydroxybutyrate) depolymerase
3.1.1.76 poly(3-hydroxyoctanoate) depolymerase
3.1.1.77 acyloxyacyl hydrolase
3.1.1.78 polyneuridine-aldehyde esterase
3.1.1.79 hormone-sensitive lipase
3.1.1.80 acetylajmaline esterase
3.1.1.81 quorum-quenching N-acyl-homoserine lactonase
3.1.1.82 pheophorbidase
3.1.1.83 monoterpene ε-lactone hydrolase
3.1.1.84 cocaine esterase
3.1.1.85 pimelyl-[acyl-carrier protein] methyl ester esterase
3.1.1.86 rhamnogalacturonan acetylesterase
3.1.1.87 fumonisin B1 esterase
3.1.1.88 pyrethroid hydrolase
3.1.1.89 protein phosphatase methylesterase-1
3.1.1.90 all-trans-retinyl ester 13-cis isomerohydrolase
3.1.1.91 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase
3.1.1.92 4-sulfomuconolactone hydrolase
3.1.1.93 mycophenolic acid acyl-glucuronide esterase
3.1.1.94 versiconal hemiacetal acetate esterase
3.1.1.95 aclacinomycin methylesterase
3.1.1.96 D-aminoacyl-tRNA deacylase
3.1.1.97 methylated diphthine methylhydrolase
3.1.1.98 [Wnt protein] O-palmitoleoyl-L-serine hydrolase
3.1.1.99 6-deoxy-6-sulfogluconolactonase
3.1.1.100 chlorophyllide a hydrolase
3.1.1.101 poly(ethylene terephthalate) hydrolase
3.1.1.102 mono(ethylene terephthalate) hydrolase
3.1.1.103 teichoic acid D-alanine hydrolase
3.1.1.104 5-phospho-D-xylono-1,4-lactonase
3.1.1.105 3-O-acetylpapaveroxine carboxylesterase
3.1.1.106 O-acetyl-ADP-ribose deacetylase
3.1.1.107 apo-salmochelin esterase
3.1.1.108 iron(III)-enterobactin esterase
3.1.1.109 iron(III)-salmochelin esterase
3.1.1.110 xylono-1,5-lactonase
3.1.1.111 phosphatidylserine sn-1 acylhydrolase
3.1.1.112 isoamyl acetate esterase
3.1.1.113 ethyl acetate hydrolase
3.1.1.114 methyl acetate hydrolase
3.1.1.115 D-apionolactonase
3.1.1.116 sn-1-specific diacylglycerol lipase
3.1.1.117 (4-O-methyl)-D-glucuronate—lignin esterase
3.1.1.118 phospholipid sn-1 acylhydrolase
3.1.1.119 exo-acting protein-α-N-acetylgalactosaminidase
3.1.2 Thioester hydrolases
3.1.3 Phosphoric-monoester hydrolases
3.1.4 Phosphoric-diester hydrolases
3.1.5 Triphosphoric-monoester hydrolases
3.1.6 Sulfuric-ester hydrolases
3.1.7 Diphosphoric-monoester hydrolases
3.1.8 Phosphoric-triester hydrolases
3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters
3.1.12 Exodeoxyribonucleases producing 3′-phosphomonoesters
3.1.13 Exoribonucleases producing 5′-phosphomonoesters
3.1.14 Exoribonucleases producing 3'-phosphomonoesters
3.1.15 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters
3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters
3.1.23 Site-specific endodeoxyribonucleases: cleavage is sequence specific (deleted sub-subclass)
3.1.23.1 created 1978, deleted 1984
3.1.23.2 created 1978, deleted 1984
3.1.23.3 created 1978, deleted 1984
3.1.23.4 created 1978, deleted 1984
3.1.23.5 created 1978, deleted 1984
3.1.23.6 created 1978, deleted 1984
3.1.23.7 created 1978, deleted 1984
3.1.23.8 created 1978, deleted 1984
3.1.23.9 created 1978, deleted 1984
3.1.23.10 created 1978, deleted 1984
3.1.23.11 created 1978, deleted 1984
3.1.23.12 created 1978, modified 1982, deleted 1984
3.1.23.13 created 1978, deleted 1984
3.1.23.14 created 1978, deleted 1984
3.1.23.15 created 1978, deleted 1984
3.1.23.16 created 1978, deleted 1984
3.1.23.17 created 1978, deleted 1984
3.1.23.18 created 1978, deleted 1984
3.1.23.19 created 1978, deleted 1984
3.1.23.20 created 1978, deleted 1984
3.1.23.21 created 1978, deleted 1984
3.1.23.22 created 1978, deleted 1984
3.1.23.23 created 1978, deleted 1984
3.1.23.24 created 1978, deleted 1984
3.1.23.25 created 1978, deleted 1984
3.1.23.26 created 1978, deleted 1984
3.1.23.27 created 1978, deleted 1984
3.1.23.28 created 1978, deleted 1984
3.1.23.29 created 1978, deleted 1984
3.1.23.30 created 1978, modified 1982, deleted 1984
3.1.23.31 created 1978, deleted 1984
3.1.23.32 created 1978, modified 1982, deleted 1984
3.1.23.33 created 1978, deleted 1984
3.1.23.34 created 1978, deleted 1984
3.1.23.35 created 1978, deleted 1984
3.1.23.36 created 1978, deleted 1984
3.1.23.37 created 1978, deleted 1984
3.1.23.38 created 1978, deleted 1984
3.1.23.39 created 1978, deleted 1984
3.1.23.40 created 1978, deleted 1984
3.1.23.41 created 1978, deleted 1984
3.1.23.42 created 1978, deleted 1984
3.1.23.43 created 1978, modified 1982, deleted 1984
3.1.23.44 created 1978, deleted 1984
3.1.23.45 created 1978, modified 1982, deleted 1984
3.1.23.46 created 1982, deleted 1984
3.1.23.47 created 1982, deleted 1984
3.1.23.48 created 1982, deleted 1984
3.1.23.49 created 1982, deleted 1984
3.1.23.50 created 1982, deleted 1984
3.1.23.51 created 1982, deleted 1984
3.1.23.52 created 1982, deleted 1984
3.1.23.53 created 1982, deleted 1984
3.1.23.54 created 1982, deleted 1984
3.1.23.55 created 1982, deleted 1984
3.1.23.56 created 1982, deleted 1984
3.1.23.57 created 1982, deleted 1984
3.1.23.58 created 1982, deleted 1984
3.1.23.59 created 1982, deleted 1984
3.1.23.60 created 1982, deleted 1984
3.1.23.61 created 1982, deleted 1984
3.1.23.62 created 1982, deleted 1984
3.1.23.63 created 1982, deleted 1984
3.1.23.64 created 1982, deleted 1984
3.1.23.65 created 1982, deleted 1984
3.1.23.66 created 1982, deleted 1984
3.1.23.67 created 1982, deleted 1984
3.1.23.68 created 1982, deleted 1984
3.1.23.69 created 1982, deleted 1984
3.1.23.70 created 1982, deleted 1984
3.1.23.71 created 1982, deleted 1984
3.1.23.72 created 1982, deleted 1984
3.1.23.73 created 1982, deleted 1984
3.1.23.74 created 1982, deleted 1984
3.1.23.75 created 1982, deleted 1984
3.1.23.76 created 1982, deleted 1984
3.1.23.77 created 1982, deleted 1984
3.1.23.78 created 1982, deleted 1984
3.1.23.79 created 1982, deleted 1984
3.1.23.80 created 1982, deleted 1984
3.1.23.81 created 1982, deleted 1984
3.1.23.82 created 1982, deleted 1984
3.1.23.83 created 1982, deleted 1984
3.1.23.84 created 1982, deleted 1984
3.1.23.85 created 1982, deleted 1984
3.1.23.86 created 1982, deleted 1984
3.1.23.87 created 1982, deleted 1984
3.1.23.88 created 1982, deleted 1984
3.1.23.89 created 1982, deleted 1984
3.1.23.90 created 1982, deleted 1984
3.1.23.91 created 1982, deleted 1984
3.1.23.92 created 1982, deleted 1984
3.1.23.93 created 1982, deleted 1984
3.1.23.94 created 1982, deleted 1984
3.1.23.95 created 1982, deleted 1984
3.1.23.96 created 1982, deleted 1984
3.1.23.97 created 1982, deleted 1984
3.1.23.98 created 1982, deleted 1984
3.1.23.99 created 1982, deleted 1984
3.1.23.100 created 1982, deleted 1984
3.1.23.101 created 1982, deleted 1984
3.1.23.102 created 1982, deleted 1984
3.1.23.103 created 1982, deleted 1984
3.1.23.104 created 1982, deleted 1984
3.1.23.105 created 1982, deleted 1984
3.1.23.106 created 1982, deleted 1984
3.1.23.107 created 1982, deleted 1984
3.1.23.108 created 1982, deleted 1984
3.1.23.109 created 1982, deleted 1984
3.1.24 Site specific endodeoxyribonucleases: cleavage is not sequence specific (deleted sub-subclass)
3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases
3.1.26 Endoribonucleases producing 5'-phosphomonoesters
3.1.27 Endoribonucleases producing 3'-phosphomonoesters
3.1.30 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.31 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases