Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

EC 1.14.21.12 Details
EC number
1.14.21.12
Accepted name
(S)-nandinine synthase
Reaction
(S)-scoulerine + NADPH + H+ + O2 = (S)-nandinine + NADP+ + 2 H2O
Other name(s)
CYP719A3
Systematic name
(S)-scoulerine,NADPH:oxygen oxidoreductase [(S)-nandinine-forming]
Comment
A cytochrome P-450 heme-thiolate enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid (S)-nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-scoulerine. cf. EC 1.14.21.2, (S)-cheilanthifoline synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-cheilanthifoline.
History
created 2016, deleted 2018
EC Tree
3.1.1.9 created 1961, deleted 1972
3.1.1.12 created 1961, deleted 1972
3.1.1.16 created 1961, deleted 1972
3.1.1.18 created 1961, deleted 1982
3.1.1.62 created 1989, deleted 1992
3.1.1.69 created 1992, deleted 2002