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EC 3.1.1.64 Details
EC number
3.1.1.64
Accepted name
retinoid isomerohydrolase
Reaction
an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid
Other name(s)
all-trans-retinyl-palmitate hydrolase (ambiguous), retinol isomerase (ambiguous), all-trans-retinol isomerase:hydrolase (ambiguous), all-trans-retinylester 11-cis isomerohydrolase, RPE65 (gene name)
Systematic name
all-trans-retinyl ester acylhydrolase, 11-cis retinol-forming
CAS registry number
106389-24-6
Comment
This enzyme, which operates in the retinal pigment epithelium (RPE), catalyses the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol, a key step in the regeneration of the visual chromophore in the vertebrate visual cycle [4]. Interaction of the enzyme with the membrane is critical for its enzymic activity [6].
History
created 1989 (EC 5.2.1.7 created 1989, incorporated 2011), modified 2011
EC Tree
3.1.1.9 created 1961, deleted 1972
3.1.1.12 created 1961, deleted 1972
3.1.1.16 created 1961, deleted 1972
3.1.1.18 created 1961, deleted 1982
3.1.1.62 created 1989, deleted 1992
3.1.1.69 created 1992, deleted 2002