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EC 3.1.4.37 Details
show Brenda entryEC number
3.1.4.37
Accepted name
2′,3′-cyclic-nucleotide 3′-phosphodiesterase
Reaction
nucleoside 2′,3′-cyclic phosphate + H2O = nucleoside 2′-phosphate
Other name(s)
cyclic-CMP phosphodiesterase,
2′,3′-cyclic AMP phosphodiesterase,
cyclic 2′,3′-nucleotide 3′-phosphodiesterase,
cyclic 2′,3′-nucleotide phosphodiesterase,
2′,3′-cyclic nucleoside monophosphate phosphodiesterase,
2′,3′-cyclic nucleotide 3′-phosphohydrolase,
CNPase,
2′,3′-cyclic nucleotide phosphohydrolase,
2′:3′-cyclic nucleotide 3′-phosphodiesterase,
2′:3′-CNMP-3′-ase
Systematic name
nucleoside-2′,3′-cyclic-phosphate 2′-nucleotidohydrolase
CAS registry number
60098-35-3
Comment
The brain enzyme acts on 2′,3′-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2′,3′-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3′,5′-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.
History
created 1976
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1 Oxidoreductases
3 Hydrolases
3.1.1.9 created 1961, deleted 1972 3.1.1.12 created 1961, deleted 1972 3.1.1.16 created 1961, deleted 1972 3.1.1.18 created 1961, deleted 1982 3.1.1.62 created 1989, deleted 1992 3.1.1.69 created 1992, deleted 2002
