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EC 1.1.1.284 Details
show Brenda entryEC number
1.1.1.284
Accepted name
S-(hydroxymethyl)glutathione dehydrogenase
Reaction
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+
Other name(s)
NAD-linked formaldehyde dehydrogenase (incorrect),
formaldehyde dehydrogenase (incorrect),
formic dehydrogenase (incorrect),
class III alcohol dehydrogenase,
ADH3,
χ -ADH,
FDH (incorrect),
formaldehyde dehydrogenase (glutathione) (incorrect),
GS-FDH (incorrect),
glutathione-dependent formaldehyde dehydrogenase (incorrect),
GD-FALDH,
NAD- and glutathione-dependent formaldehyde dehydrogenase,
NAD-dependent formaldehyde dehydrogenase (incorrect)
Systematic name
S-(hydroxymethyl)glutathione:NAD+ oxidoreductase
Comment
The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase. This enzyme forms part of the pathway that detoxifies formaldehyde, since the product is hydrolysed by EC 3.1.2.12, S-formylglutathione hydrolase. The human enzyme belongs to the family of zinc-dependent alcohol dehydrogenases. Also specifically reduces S-nitrosylglutathione.
History
created 2005 (EC 1.2.1.1 created 1961, modified 1982, modified 2002, part transferred 2005 to EC 1.1.1.284)
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1 Oxidoreductases
