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EC 1.1.5.2 Details
EC number
1.1.5.2
Accepted name
glucose 1-dehydrogenase (PQQ, quinone)
Reaction
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
Other name(s)
quinoprotein glucose dehydrogenase,
membrane-bound glucose dehydrogenase,
mGDH,
glucose dehydrogenase (PQQ-dependent),
glucose dehydrogenase (pyrroloquinoline-quinone),
quinoprotein D-glucose dehydrogenase
Systematic name
D-glucose:ubiquinone oxidoreductase
CAS registry number
81669-60-5
Comment
Integral membrane protein containing PQQ as prosthetic group. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.
History
created 1982 as EC 1.1.99.17, transferred 2003 to EC 1.1.5.2, modified 2010