EC Explorer

1.1.5.2

glucose 1-dehydrogenase (PQQ, quinone)

D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol

quinoprotein glucose dehydrogenase, membrane-bound glucose dehydrogenase, mGDH, glucose dehydrogenase (PQQ-dependent), glucose dehydrogenase (pyrroloquinoline-quinone), quinoprotein D-glucose dehydrogenase

D-glucose:ubiquinone oxidoreductase

81669-60-5

Integral membrane protein containing PQQ as prosthetic group. It also contains bound ubiquinone and Mg²⁺ or Ca²⁺. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.

created 1982 as EC 1.1.99.17, transferred 2003 to EC 1.1.5.2, modified 2010